Pierre Bruhns Selected Research

IgG Receptors (Fc gamma RI)

1/2020	The anti-IgE mAb omalizumab induces adverse reactions by engaging Fcγ receptors.
1/2018	Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis.
4/2017	Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice.
1/2016	Inhibitory IgG Receptor-Expressing Cells: The Must-Have Accessory for Anti-CD40 Immunomodulatory mAb Efficacy.
2/2013	The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy.
6/2012	Properties of mouse and human IgG receptors and their contribution to disease models.
3/2012	Human FcγRIIA induces anaphylactic and allergic reactions.
4/2011	Mouse and human neutrophils induce anaphylaxis.
3/2011	Cutting edge: intravenous Ig inhibits invariant NKT cell-mediated allergic airway inflammation through FcγRIIIA-dependent mechanisms.
2/2011	Cutting Edge: The murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis.

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Pierre Bruhns Research Topics

Disease

13	Anaphylaxis (Anaphylactic Shock) 01/2021 - 04/2011
11	Inflammation (Inflammations) 01/2020 - 04/2003
7	Neoplasms (Cancer) 01/2020 - 02/2013
6	Arthritis (Polyarthritis) 06/2017 - 04/2003
5	Hypersensitivity (Allergy) 01/2020 - 12/2005
4	Asthma (Bronchial Asthma) 01/2022 - 01/2020
3	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 01/2022 - 05/2005
3	Melanoma (Melanoma, Malignant) 10/2013 - 12/2012
2	Infections 01/2022 - 01/2016
2	Autoimmune Diseases (Autoimmune Disease) 01/2019 - 04/2003
2	HIV Infections (HIV Infection) 01/2019 - 01/2018
2	Breast Neoplasms (Breast Cancer) 07/2014 - 10/2013
2	Thrombocytopenia (Thrombopenia) 07/2005 - 05/2005
1	COVID-19 12/2021
1	Respiratory Hypersensitivity 11/2021
1	Eosinophilia 11/2021
1	Chronic Urticaria 01/2020
1	Muscular Diseases (Myopathy) 01/2019
1	Hypothermia 01/2017
1	Endotoxemia 01/2017
1	Malaria 01/2016
1	Ulcer 05/2015
1	Wiskott-Aldrich Syndrome 05/2015
1	Rheumatoid Arthritis 09/2014
1	Neoplasm Metastasis (Metastasis) 12/2012
1	Experimental Melanoma 12/2012
1	Neutropenia 09/2012
1	Wasting Syndrome (Wasting Disease) 01/2011
1	Pneumonia (Pneumonitis) 11/2008

Drug/Important Bio-Agent (IBA)

16	Immunoglobulin G (IgG)IBA 01/2022 - 01/2011
11	IgG Receptors (Fc gamma RI)IBA 01/2020 - 04/2003
8	AntibodiesIBA 01/2022 - 07/2005
8	Immunoglobulin E (IgE)IBA 11/2021 - 11/2008
6	Intravenous Immunoglobulins (IVIG)FDA Link 01/2019 - 04/2003
5	Antigen-Antibody Complex (Immune Complex)IBA 01/2020 - 09/2012
4	Interleukin-4 (Interleukin 4)IBA 01/2022 - 01/2019
4	VaccinesIBA 01/2022 - 01/2016
4	Monoclonal AntibodiesIBA 11/2021 - 12/2012
4	Fc Receptors (Fc Receptor)IBA 01/2017 - 12/2005
4	AutoantibodiesIBA 09/2012 - 04/2003
3	CytokinesIBA 01/2022 - 11/2014
3	Interleukin-13IBA 01/2022 - 11/2021
3	Immunoglobulin IsotypesIBA 01/2022 - 10/2019
3	AntigensIBA 01/2022 - 02/2014
3	Pharmaceutical PreparationsIBA 01/2021 - 01/2018
3	IgE Receptors (Fc epsilon RI)IBA 03/2012 - 12/2005
2	Inosine Triphosphate (ITP)IBA 01/2022 - 05/2005
2	Immunoglobulins (Immunoglobulin)IBA 12/2021 - 02/2014
2	AllergensIBA 10/2019 - 01/2017
2	Trastuzumab (Herceptin)FDA Link 01/2019 - 07/2014
2	Histamine (Histamine Dihydrochloride)FDA Link 01/2017 - 01/2017
1	Conjugate VaccinesIBA 11/2021
1	Multifunctional EnzymesIBA 01/2020
1	Omalizumab (Xolair)FDA Link 01/2020
1	anti-IgE antibodiesIBA 01/2020
1	Neuromuscular Blocking AgentsIBA 10/2019
1	Bone Marrow Stromal Antigen 2IBA 01/2019
1	chenodeoxycholate sulfate conjugate (CDCS)IBA 01/2019
1	Interleukin-33IBA 01/2019
1	Rituximab (Mabthera)FDA Link 01/2019
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2019
1	Serotonin (5 Hydroxytryptamine)IBA 01/2018
1	platelet activating factor receptorIBA 04/2017
1	Histamine Receptors (Histamine Receptor)IBA 04/2017
1	Liposomes (Liposome)IBA 01/2017
1	Clodronic Acid (Clodronate)IBA 01/2017
1	Diphtheria ToxinIBA 01/2017
1	Platelet Activating FactorIBA 01/2017
1	EndotoxinsIBA 01/2017
1	EnzymesIBA 01/2017
1	Peroxidase (Myeloperoxidase)IBA 01/2017
1	Interleukin-6 (Interleukin 6)IBA 01/2016
1	Translationally-Controlled 1 Tumor ProteinIBA 01/2016
1	Angiotensin IIIBA 05/2015
1	mycolactoneIBA 05/2015
1	Proteins (Proteins, Gene)FDA Link 05/2015
1	Tyrosine (L-Tyrosine)FDA Link 09/2014
1	hippuryl-glycyl-glycine (HIGG)IBA 09/2014
1	EpitopesIBA 07/2014
1	Neoplasm Antigens (Tumor Antigens)IBA 10/2013
1	Glycoproteins (Glycoprotein)IBA 12/2012
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2012
1	Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA 09/2012
1	P-SelectinIBA 05/2005
1	PhosphatidylserinesIBA 05/2005
1	Fc gamma receptor IIBIBA 04/2003
1	Immunoglobulin Fc FragmentsIBA 04/2003

Therapy/Procedure

5	Therapeutics 11/2014 - 04/2011
4	Immunotherapy 06/2017 - 02/2013
1	General Anesthesia 10/2019
1	Highly Active Antiretroviral Therapy (HAART) 01/2018
1	Analgesia 05/2015